The active substance binds to so-called sterols, which are located on the fungal membrane. This causes the cell membrane to lose its tightness and potassium to flow out of the cell, causing cell death. Especially the active substance natamycin, which is mostly used in ophthalmology, has a broad spectrum of action against fungi and yeasts.
Fields of application
Natamycin is used, among other things, in the case of Fusarium infection of the cornea of the eye. An improvement of the symptoms can be expected already after two days. Before using this drug, it is important to determine whether the fungus is actually a fungus and whether the fungus is sensitive to the active ingredient. Natamycin is available as an eye ointment and should be taken 6 times a day (Pima Biciron).
After prolonged use, eyelid swelling and pain may occur. Obstructions of the tear duct system of the eye have also been described, which can lead to a dripping and watery eye. In rare cases allergic reactions have been described.
The drug should not be used in patients who are already known to be allergic to natamycin. Furthermore, a combination with cortisone-containing medication should be avoided, as this could lead to a carry-over of the fungus.