Eyelid Diseases: Or something else? Differential Diagnosis

Eyes and ocular appendages (H00-H59).

  • Acute inflammation of the orbit (eye socket).
  • Blepharitis (inflammation of the eyelid margin)
  • Blepharospasm (eyelid spasm)
  • Chalazion (hailstone)
  • Dacryocystitis (inflammation of the lacrimal sac)
  • Ectropion – outward rotation of the eyelid.
  • Entropion (rolled eyelid) – inward rotation of the eyelid; possibly also the presence of trichiasis (eyelash rubbing; rubbing eyelashes on the cornea or conjunctiva of the eye).
  • Hordeolum (sty)
  • Eyelid eczema
  • Myokymia – involuntary muscle activity in the form of brief tetanic contractions in muscle fibers of the orbicularis oculi/ocular ring muscle.
  • Ptosis – drooping eyelid; may occur v. a. in:
    • Chronic progressive external ophthalmoplegia (CPEO) – progressive (progressive) paralysis of the external eye muscles due to mitochondrial dysfunction (mitochondriopathy/diseases caused by damage to or malfunction of mitochondria (“power plants of cells”)).
    • Horner syndrome – triad associated with miosis (pupil constriction), ptosis (drooping of the upper eyelid) and pseudoenophthalmos (apparently sunken eyeball).
    • Paralysis of the oculomotor nerve (III cranial nerve).
    • Congenital (“congenital”) ptosis: aplasia of the oculomotor nucleus section (disturbance of the cranial nerve), which innervates (supplied with nerve fibers) the levator palpebrae muscle (eyelid lifter).
    • Myasthenia gravis (MG; synonyms: myasthenia gravis pseudoparalytica; MG); rare neurologic autoimmune disorder in which specific antibodies against the acetylcholine receptors are present, with characteristic symptoms such as abnormal load-dependent and painless muscle weakness, asymmetry, in addition to local, also temporal variability (fluctuation) over the course of hours, days or Weeks, an improvement after recovery or rest periods; clinically can be differentiated a purely ocular (“affecting the eye”), a faciopharyngeal (face (Facies) and pharynx (pharynx)) emphasized and a generalized myasthenia; about 10% of cases already show a manifestation in childhood.
    • Senile myotonic dystrophymuscular weakness that occurs in old age.
  • Narrowed tear duct
  • Xanthelasma – reddish-yellow deposits in the skin.

Skin and subcutaneous tissue (L00-L99)

  • Alopecia (hair loss)

Infectious and parasitic diseases (A00-B99).

Neoplasms – tumor diseases (C00-D48)

  • Neoplasms in the region of the eye, unspecified.

Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99)

  • Nephrotic syndrome – collective term for symptoms that occur in various diseases of the glomerulus (renal corpuscles); the symptoms are proteinuria (increased excretion of protein in the urine) with a loss of protein; hypoproteinemia, peripheral edema (water retention) due to hypoalbuminemia (decreased level of albumin in the blood), hyperlipoproteinemia (lipid metabolism disorder).

Injuries, poisonings, and other consequences of external causes (S00-T98).

  • Angioedema – massive swelling of the subcutis (submucosa) or submucosa (submucosal connective tissue), usually affecting the lips and eyelids, but may also involve the tongue or other organs

Other causes

  • Insect bite