Facial Redness (Flushing): Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90).

Skin and subcutaneous (L00-L99).

  • Atopic eczema (AE), colloquially neurodermatitis (in terms of facial redness).
  • Rosacea (copper rose) – chronic inflammatory, non-contagious skin disease that manifests on the face; papules (nodules) and pustules (pustules) and telangiectasias (dilation of small, superficial skin vessels) are typical.

Cardiovascular system (I00-I99).

Neoplasms – tumor diseases (C00-D48).

  • ACTH-secreting bronchogenic carcinoma (lung cancer).
  • Catecholamine-producing tumors-neoplasms such as pheochromocytoma (tumor of the adrenal gland) that produce catecholamines such as norepinephrine
  • Mastocytosis – two main forms: cutaneous mastocytosis (skin mastocytosis) and systemic mastocytosis (whole body mastocytosis); clinical picture of cutaneous mastocytosis: Yellowish-brown spots of varying size (urticaria pigmentosa); in systemic mastocytosis, there are also episodic gastrointestinal complaints (gastrointestinal complaints), (nausea (nausea), burning abdominal pain and diarrhea (diarrhea)), ulcer disease, and gastrointestinal bleeding (gastrointestinal bleeding) and malabsorption (disorder of food absorption); in systemic mastocytosis, there is an accumulation of mast cells (cell type involved, among other things, in allergic reactions). Among other things, involved in allergic reactions) in the bone marrow, where they are formed, as well as accumulation in the skin, bones, liver, spleen and gastrointestinal tract (GIT; gastrointestinal tract); mastocytosis is not curable; course usually benign (benign) and life expectancy normal; extremely rare degeneration mast cells (= mast cell leukemia (blood cancer)).
  • Medullary thyroid carcinoma – form of thyroid cancer that produces calcitonin.
  • Renal cell carcinoma (renal cell cancer).
  • POEMS syndrome (synonym: Crow-Fukase syndrome) – rare variant of multiple myeloma resp. associated paraneoplasia (symptoms and findings resulting from distant tumor involvement): Coexistence of peripheral neuropathy (P; damage to peripheral nerves), monoclonal plasmacytoma (M), and other paraneoplastic symptoms, most commonly organomegaly (O; abnormal, often pathologic, enlargement of one or more organs), endocrinopathy (E; diseases affecting the endocrine system), and skin lesions (skin, S); age of manifestation: adulthood, older adults.
  • Plasmocytoma (multiple myeloma) – malignant (malignant) systemic disease. It belongs to the non-Hodgkin’s lymphomas of B lymphocytes.
  • Polycythaemia vera – disease in which there is an increase in all three blood cell series (especially erythrocytes, but also platelets (blood platelets) and leukocytes / white blood cells) in the blood.
  • Serotonin-producing carcinoids (synonyms: diffuse neuroendocrine neoplasia (neoplasm); neuroendocrine tumors, NET; gastoenteropancreatic neuroendocrine neoplasia (GEP-NEN)) – localization: Depending on the localization, the following are distinguished: the bronchus carcinoid, thymus carcinoid, appendix carcinoid, ileum carcinoid, duodenal carcinoid, gastric carcinoid, rectal carcinoid (colon NET), pancreatic carcinoid (pancreatic NET); approx. 80 percent of tumors are located in the terminal ileum or appendix.Symptoms: The first sign is often persistent diarrhea. Typical for the carcinoids (GEP-NEN) is the “flush symptomatology” (flush syndrome); this is a sudden blue-red discoloration of the face, neck and under certain circumstances of the torso understood, furthermore hypoglycemias (hypoglycemia) or duodenal ulcers (ulcers of the duodenum).
  • Vasoactive intestinal peptide (VIP)-producing tumors – neoplasms that produce hormones that are physiologically synthesized in the digestive tract.

Psyche – nervous system (F00-F99; G00-G99).

  • Alcohol abuse (chronic alcohol abuse).
  • Epilepsy (aura)
  • Seizures originating from the diencephalon.
  • Somatoform disorder – mental illness that results in physical symptoms without physical findings to be collected

Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99).

Injuries, poisonings, and other consequences of external causes (S00-T98).

Factors influencing health status and leading to health care utilization (Z00-Z99).

  • Stress: erythema e pudore – on exertion and excitement (due tosympathicoton mediated vasodilation).

Further

  • Alcohol (Facies alcoholica)
  • Phototoxic and photoallergic reactions.
  • Postmenopausal women (intermittent and sometimes seizure-like).
  • Glutamate intake
  • Heat
  • Spicy food with capsaicin (CPS); from plants of the genus Capsicum (peppers, of the nightshade family Solanaceae).

Drugs