Effects
Fibrates (ATC C10AB) have lipid-lowering properties. They primarily lower elevated blood triglyceride levels and have a moderate effect on LDL cholesterol and slightly increase HDL. The effects are due to activation of nuclear receptors PPAR (mainly PPARα).
Indications
Blood lipid disorders, especially hypertriglyceridemia.
Agents
- Bezafibrate (Cedur retard)
- Fenofibrate (Lipanthyl)
- Fenofibric acid (Trilipix)
- Gemfibrozil (Gevilon)
Out of commerce in many countries:
- Ciprofibrate (Hyperlipen)
- Clofibrate – first fibrate
- Etofibrate (Lipo-Merz)
