Products
Follitropin delta was approved in the EU in 2016 and in many countries in 2017 as [solution for injection>injections] (recovelle).
Structure and properties
Follitropin delta is a recombinant human follicle-stimulating hormone (FSH) with the same amino acid sequences as the natural hormone. Follitropin delta is produced in the human cell line PER.C6 and differs in glycosylation profile from follitropin alfa and follitropin beta, which are produced in CHO cells. FSH is a heterodimer and consists of two distinct glycoproteins, the α-subunit (92 amino acids) and the β-subunit (111 amino acids), which are non-covalently bound to each other. FSH is a hormone of the anterior pituitary gland that plays an important role in follicular maturation and spermatogenesis.
Effects
Follitropin delta (ATC G03GA10) leads to the development of multiple mature follicles.
Indications
Controlled ovarian stimulation to develop multiple follicles in women undergoing assisted reproductive techniques such as in vitro fertilization or intracytoplasmic sperm injection.
Dosage
According to the SmPC. The drug is administered subcutaneously
Contraindications
For complete precautions, see the drug label.
Adverse effects
The most common possible adverse effects include headache, abdominal discomfort, OHSS (ovarian hyperstimulation syndrome), abdominal pain, nausea, pain of the female appendages, and fatigue.
