Four Period Pill

Products

The so-called four-period pill Seasonique was approved in many countries in 2016. It has been available in the United States since 2006, and in several European countries since 2015. One pack of Seasonique contains:

Unlike ordinary pills, the period between withdrawal bleeding is much longer. The conventional pills are usually taken only during 21 days, for 3 weeks.

Structure and properties

Ethinylestradiol is an estrogen and levonorgestrel is a progestin:

Effects

The active ingredients have contraceptive properties. The effects are primarily due to inhibition of ovulation and alteration of cervical secretions. Furthermore, the pill inhibits implantation of the egg (nidation) by altering the lining of the uterus.

Indications

For hormonal contraception.

Dosage

According to the SmPC. The film-coated tablets are taken once daily continuously for 91 days (= 13 weeks). Subsequently, the new pack is started without a break. After 84 days (12 weeks), the white tablets containing only ethinyl estradiol are administered for one week. During this period, withdrawal bleeding usually occurs.

Contraindications

For complete precautions, see the drug label.

Adverse effects

The most common possible adverse effects include irregular and/or heavy uterine bleeding weight gain and acne. In addition, numerous other side effects are possible. Like other hormonal contraceptives, the four-period pill increases the risk of arterial and venous thromboembolic disease.