Products
Gestodene is marketed in many countries exclusively in combination with ethinyl estradiol in the form of dragées and film-coated tablets as an oral contraceptive (“pill”). It has been approved in many countries since 1986.
Structure and properties
Gestodene (C21H26O2, Mr = 310.4 g/mol) exists as a white to yellowish crystalline powder that is practically insoluble in water.
Effects
Gestodene (ATC G03AB06) has contraceptive properties. The effects are primarily due to inhibition of ovulation. The half-life is 16 to 18 hours.
Indications
In combination with an estrogen for oral hormonal contraception.
Dosage
According to the SmPC. The tablets are taken once daily at the same time of day for 21 days. This is followed by a break from taking the tablets for 7 days. Subsequently, the next intake cycle is started.
Contraindications
For complete precautions, see the drug label.
Adverse effects
The most common possible adverse effects include headache and breakthrough bleeding. This when combined with ethinyl estradiol.
