Giant Cell Tumor (Osteoclastoma): Test and Diagnosis

Laboratory parameters of 1st order – obligatory laboratory tests.

  • Biopsy (tissue sample) – for differential diagnostic reasons.
  • Immunohistochemical detection of mutant H3.3 histone protein – for unclear cases.
  • Parathyroid hormone – to exclude hyperparathyroidism, in the setting of which osseous manifestations of the disease may occur: Osteodystrophia cystica generalisata von Recklinghausen (bled resorption cysts = brown tumors with irregularly distributed giant cell clusters) (rather rare).