Products
Goserelin is commercially available as a solid depot (Zoladex, generic). It has been approved in many countries since 1990.
Structure and properties
Goserelin is an analog of gonadotropin-releasing hormone (GnRH) and is present in drugs as goserelin acetate, a decapeptide and white powder that is soluble in water.
- Goserelin: Pyr-Glu-His-Trp-Ser-Tyr-D-Ser(But)-Leu-Arg-Pro-Azgly.
- GnRH: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly
Effects
Goserelin (ATC L02AE03), when used for a short period of time, causes increased secretion of LH and FSH, resulting in an increase in estrogen and testosterone levels. With long-term administration, hormone levels drop within a month.
Indications
- Prostate cancer
- Breast carcinoma
- Endometriosis
- Uterine fibroid
- Endometrial ablatio
- In reproductive medicine
Dosage
According to the professional information.
Contraindications
- Hypersensitivity
- Vaginal bleeding that has not been clarified
- Pregnancy and lactation
Full precautions can be found in the drug label.
Interactions
There are no known drug-drug interactions.
Adverse effects
The most common possible adverse effects include acne, flushing, sweating, headache, mood changes, depression, breast enlargement, vaginal dryness, decrease in libido, erectile dysfunction, and local reactions at the injection site.
