Granulomatosis with Polyangiitis: Complications

The following are the major diseases or complications that may be contributed to by granulomatosis with polyangiitis (GPA), formerly Wegener’s granulomatosis:

Respiratory system (J00-J99)

  • Pulmonary syndrome – combination of renal and pulmonary vasculitis (inflammation of the (mostly) arterial blood vessels in the kidneys and lungs), including necrotizing extracapillary proliferative glomerulonephritis (inflammation of the glomeruli (renal corpuscles) of the kidneys)

Eyes and eye appendages (H00-H59).

  • Episcleritis – inflammation of connective tissue layers on the sclera (3.5%).
  • Keratoconjunctivitis sicca (KCS) – inflammation of the conjunctiva associated with decreased tear secretion and keratitis (4-15%).
  • Pseudotumor orbitae – nonspecific inflammatory infiltration of the orbit (bony orbit), which usually occurs unilaterally.
  • Scleritis – inflammation of the sclera (16-38%).

Cardiovascular system (I00-I99)

Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99).

  • Pulmonary hemorrhage

Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99)

  • Acute renal failure (ANV)

Further

  • Acute organ failure, unspecified