The following symptoms and complaints may indicate granulomatosis with polyangiitis (GPA), formerly Wegener’s granulomatosis, (as defined by EUVAS):
- Fatigue
- Acute dyspnea (shortness of breath)
- General weakness
- Anorexia (loss of appetite)
- Arthralgia (joint pain)
- Eyelid / lower leg edema (water retention).
- Cephalgia (headache), due to hypertension (high blood pressure).
- Chronic bloody-crusted rhinitis (inflammation of the nasal mucosa).
- Chronic otitis media (inflammation of the middle ear).
- Eyes
- Episcleritis (inflammation of the episclera (highly perfused, loose layer of connective tissue separating the sclera (sclera) from the tunica conjunctiva (conjunctiva) at the anterior margin of the eye)).
- Exophthalmos (protrusion of the eye from the orbit).
- Peripheral keratomalacia (softening (malacia) with melting and opacity of the cornea of the eye) – as a corneal manifestation.
- Visual disturbances
- Increased temperature/fever
- Gait unsteadiness
- Weight loss
- Glomerulonephritis (inflammation of the glomeruli (renal corpuscles)), possibly “rapid progressive” form.
- Skin changes such as purpura (punctate hemorrhages) or necrosis (tissue death).
- Hemoptysis (coughing up blood)
- Hemorrhage (bleeding from the respiratory tract).
- Mastoiditis (mastoid process inflammation; purulent inflammation of the bone behind the ear).
- Fatigue
- Myalgia (muscle pain)
- Myositis (muscle inflammation)
- Night sweats
- Pharyngitis (inflammation of the throat)
- Saddle nose
- Septum perforation (hole in the nasal septum).
- Sialadenitis (inflammation of the salivary glands)
- Subglottic tracheal stenosis – tracheal narrowing below the glottis.
- Numbness/sensitivity disorders, especially in fingers and tips of feet.
- Ulcerations (ulcers) in the oropharynx (oral pharynx).