Because of the definite clinical diagnosis and mild course, laboratory diagnostics are not required in most cases.
1st-order laboratory parameters-obligatory laboratory tests.
- Virus detection by enterovirus PCR (5′-NCR) from stool samples, throat swabs, or vesicle contents:From stool, pathogen detection succeeds in the first 1-2 weeks of the disease in about 80% of cases.
- If necessary, further diagnostics for molecular typing: PCR in the protein-coding VP1 region with subsequent sequencing.
Laboratory parameters 2nd order – depending on the results of the history, physical examination, etc. – for differential diagnostic clarification.
- CSF puncture (collection of cerebrospinal fluid by puncture of the spinal canal) for CSF diagnosis – in CNS symptomatology.
