Products Melitracene is marketed in the form of film-coated tablets exclusively in combination with flupentixol (Deanxit). It has been approved in many countries since 1973. see under melitracene and flupentixol Structure and properties Melitracene (C21H25N, Mr = 291.4 g/mol) Effects Melitracene (ATC N06CA02) has antidepressant properties. Indications In combination with flupentixol: Mild to moderate states … Melitracene
Products Nortriptyline was commercially available in the form of film-coated tablets (nortrilen). It was approved in many countries in 1964. It was discontinued from distribution in 2016. Structure and properties Nortriptyline (C19H21N, Mr = 263.4 g/mol) is present in drugs as nortriptyline hydrochloride, a white powder that is sparingly soluble in water. It is an … Nortriptyline
Products Trimipramine is commercially available in tablet and drop form (Surmontil, generic). It has been approved in many countries since 1962. Structure and properties Trimipramine (C20H26N2, Mr= 294.5 g/mol) is present in drugs as trimipramine mesilate or trimipramine maleate, a racemate and white crystalline powder that is sparingly soluble in water. It is structurally closely … Trimipramine
Products Clomipramine is commercially available as sustained-release tablets and coated tablets (Anafranil). It has been approved in many countries since 1966 (originally Geigy, later Novartis). The injection and infusion preparations are no longer marketed. Structure and properties Clomipramine (C19H23ClN2, Mr = 314.9 g/mol) is present in drugs as clomipramine hydrochloride, a white to pale yellow … Clomipramine
Products Amitriptyline is commercially available as film-coated tablets and capsules (Saroten, limbitrol + chlordiazepoxide). It has been approved in many countries since 1961. The distribution of tryptizole was discontinued in 2012. Structure and properties Amitriptyline (C20H23N, Mr = 277.4 g/mol) is present in drugs as amitriptyline hydrochloride, a white powder or colorless crystals that are … Amitriptyline: Tricyclic Antidepressant
Products Doxepin is commercially available in many countries in capsule form (Sinquan) and has been approved since 1968. Structure and properties Doxepin (C19H21NO, Mr = 279.4 g/mol) is present in drugs as doxepin hydrochloride, a white crystalline powder that is readily soluble in water. It is a dibenzoxepin derivative. Effects Doxepin (ATC N06AA12) has antidepressant, … Doxepin: Drug Effects, Side Effects, Dosage and Uses
Products Imipramine was commercially available in the form of dragées (Tofranil). It was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). It was approved in many countries in 1958 as the first active ingredient in the tricyclic antidepressant group. In … Imipramine: Drug Effects, Side Effects, Dosage and Uses
Products Opipramol is commercially available in the form of dragées (Insidon). It has been approved in many countries since 1961, originally by Geigy, later by Novartis. Structure and properties Opipramol (C23H29N3O, Mr = 363.5 g/mol) structurally belongs to the tricyclic antidepressants and is a dibenzazepine derivative. It is present in the drug as opipramol dihydrochloride. … Opipramol
Products Dibenzepine was still commercially available as extended-release film-coated tablets (Noveril TR, Novartis, formerly Wander). It was approved in many countries in 1968 and withdrawn from the market in 2016. Structure and properties Dibenzepine (C18H21N3O, Mr = 295.4 g/mol) is present in drugs as dibenzepine hydrochloride. It belongs to the dibenzepine group. Effects Dibenzepine (ATC … Dibenzepine
Products Desipramine is no longer available as a drug in many countries. Pertofran dragées are out of commerce. Structure and properties Desipramine (C18H22N2, Mr = 266.4 g/mol) is the main active metabolite of imipramine (desmethylimipramine). It is present in drugs as desipramine hydrochloride, a white crystalline powder that is soluble in water. Effects Desipramine (ATC … Desipramine
