Products Azelastine is available as a nasal spray and in eye drop form (eg, Allergodil, Dymista + fluticasone, generics). It has been approved in many countries since 1994. Structure and properties Azelastine (C22H24ClN3O, Mr = 381.9 g/mol) is present in drugs as azelastine hydrochloride, a white to almost white crystalline powder. It is a phthalazinone … Azelastine
Product Cyclizine has been discontinued in many countries since 2008. Marzine is no longer available. Possible alternatives include the antihistamines dimenhydrinate or meclozine. Structure and properties Cyclizine (C18H22N2, Mr = 266.38 g/mol) is a piperazine derivative. In the drug, it is present as cyclizine hydrochloride. Effects Cyclizine (ATC R06AE03) has antihistamine, antiemetic, antivertiginous, and sedative … Cyclizine
Products Antazoline is fixed combination with tetryzoline in the form of eye drops commercially available (Spersallerg, Spersallerg SDU). It has been approved in many countries since 1967. Structure and properties Antazoline (C17H19N3, Mr = 265.35 g/mol) is present in drugs as antazoline hydrochloride, a white crystalline powder that is sparingly soluble in water. It is … Antazoline: Antihistamine
Products There are currently no drugs containing carbinoxamine on the market in many countries. The active ingredient was previously contained in Rhinotussal capsules and Rhinotussal juice, among other products. Structure and properties Carbinoxamine (C16H19ClN2O, Mr = 290.8 g/mol) is present in drugs as carbinoxamine maleate, a white crystalline powder that is readily soluble in water. … Carbinoxamine
Products Dimetinden maleate has been commercially available in many countries since 1974 in the form of a gel (Fenistil Gel). Structure and properties Dimetindene (C20H24N2, Mr = 292.4 g/mol) is present in drugs as dimetindene maleate, a white crystalline powder that is poorly soluble in water. The name is derived from the two methyl groups … Dimetinden Maleate Gel
Products Dimetinden maleate is available as oral drops (Feniallerg drops). They were formerly called Fenistil drops. The drug has been approved in many countries since 1961. Structure and properties Dimetindene (C20H24N2, Mr = 292.4 g/mol) is present in drugs as dimetindene maleate, a white crystalline powder that is poorly soluble in water. The name is … Dimetinden Maleate Drops
Products Dimenhydrinate is commercially available in the form of tablets, dragées, [chewing gum dragées>chewing gum], and capsules, among others. Since 2012, a combination with the calcium channel blocker cinnarizine has been approved in many countries (Arlevert) see under Cinnarizine and Dimenhydrinate. Structure and properties Dimenhydrinate (C24H28ClN5O3, Mr = 470.0 g/mol) is the salt of diphenhydramine … Dimenhydrinate
Products Dimetinden maleate is commercially available as drops, gel, lotion, nasal spray, and nasal drops (Fenistil, Feniallerg, Vibrocil, Otriduo). The nasal products also contain the vasoconstrictor phenylephrine. The Fenistil products used internally (systemically) were renamed Feniallerg in 2009. The capsules and dragées are no longer available. Structure and properties Dimetind (C20H24N2, Mr = 292.4 g/mol) … Dimetindenmaleate
Products Olopatadine is commercially available in the form of eye drops (Opatanol). It has been approved in many countries since 2003. Structure and properties Olopatadine (C21H23NO3, Mr = 337.41 g/mol) is present in drugs as olopatadine hydrochloride. It is a dihydrodibenzoxepin derivative with a tricyclic structure. Effects Olopatadine (ATC S01GX09) has antihistamine, antiallergic, and mast … Olopatadine
Products Ketotifen is commercially available in tablet form and as eye drops (Zaditen, Zabak). It has been approved in many countries since 1977. See also under ketotifen eye drops. Structure and properties Ketotifen (C19H19NOS, Mr = 309.43 g/mol) is a tricyclic benzocycloheptathiophene derivative structurally related to pizotifen (Mosegor, out of commerce). It is present in … Ketotifen
Products Ketotifen eye drops have been approved in many countries since 2000 (Zaditen Ophtha / -SDU, Zabak). Structure and properties Ketotifen (C19H19NOS, Mr = 309.43 g/mol) is a tricyclic benzocycloheptathiophene derivative structurally related to pizotifen (Mosegor, out of commerce). It is present in drugs as ketotifen hydrogen fumarate, a white to brownish yellow crystalline powder … Ketotifen Eye Drops
Products Emedastine is commercially available in the form of eye drops (Emadine). It has been approved in many countries since 1999. Structure and properties Emedastine (C17H26N4O, Mr = 302.41 g/mol) is a benzimidazole and a methyl diazepine derivative. It is present in drugs as emedastinidifumarate, a white powder that is soluble in water. Effects Emedastine … Emedastine
