Azathioprine (Imuran)

Products Azathioprine is commercially available as film-coated tablets and as a lyophilizate (Imurek, generic). It has been approved in many countries since 1965. Structure and properties Azathioprine (C9H7N7O2S, Mr = 277.3 g/mol) is a nitromidazole derivative of mercaptopurine. It exists as a pale yellow powder that is practically insoluble in water. Effects Azathioprine (ATC L04AX01) … Azathioprine (Imuran)

Abatacept

Products Abatacept is commercially available as an injection and infusion preparation (Orencia). It was approved in the United States in 2005 and in the EU and many countries in 2007. Structure and properties Abatacept is a recombinant fusion protein with the following components: Extracellular domain of CTLA-4 (cytotoxic T-lymphocyte-associated protein 4). Modified Fc domain of … Abatacept

Tacrolimus (Protopic, Prograf): Drug Effects, Side Effects, Dosage and Uses

Products Tacrolimus is commercially available in the form of capsules, sustained-release capsules, sustained-release tablets, as a concentrated solution for infusion, as granules, and as an ointment (Prograf, generic, Advagraf, Protopic, generic, Modigraf). It has been approved in many countries since 1996. This article refers to oral use; see also Topical Tacrolimus (Protopic Ointment). Structure and … Tacrolimus (Protopic, Prograf): Drug Effects, Side Effects, Dosage and Uses

Ciclosporin

Products Ciclosporin is commercially available as capsules, a drinkable solution, and an infusion concentrate (Sandimmune, Sandimmune Neoral, generics). It has been approved in many countries since 1995. Neoral is the microemulsion formulation that has more stable bioavailability than traditional Sandimmune. In 2016, ciclosporin eye drops were approved (see there). Structure and properties Ciclosporin (C62H111N11O12, Mr … Ciclosporin

Ciclosporin Eye Drops

Products Ciclosporin eye drops were approved in the EU in 2015 and in many countries in 2016 (Ikervis). They have been registered in the United States since 2009 (Restasis). Structure and properties Ciclosporin (C62H111N11O12, Mr = 1203 g/mol) exists as a white powder that is practically insoluble in water. It is extracted from the mushroom … Ciclosporin Eye Drops

Basiliximab

Products Basiliximab is commercially available as an injectable (Simulect, Novartis). It has been approved in many countries, in the EU, and in the United States since 1998. Structure and properties Basiliximab is a chimeric monoclonal human murine IgG1κ antibody with a molecular mass of 144 kDa. It is produced by biotechnological methods. The drug name … Basiliximab

Belatacept

Products Belatacept was approved in many countries in 2011 as a powder for the preparation of an infusion solution concentrate (Nulojix). Structure and properties Belatacept is a soluble fusion protein consisting of a modified extracellular domain of human cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and a fragment of the Fc domain of a human IgG1 antibody. … Belatacept

Ustekinumab

Products Ustekinumab is commercially available as a solution for injection (Stelara). It was newly approved in the EU in January 2009, in the United States in September 2009, and in many countries in October 2010. In 2017, a concentrate for the preparation of an infusion solution was also approved. This article refers to subcutaneous administration. … Ustekinumab

Mycophenolate

Products Mycophenolate is commercially available in the form of enteric-coated film-coated tablets (Myfortic). It has been approved in many countries since 2002. Structure and properties Mycophenolate is the deprotonated form of mycophenolic acid (C17H20O6, Mr = 320.3 g/mol). It is present in the drug as mycophenolate sodium, a white crystalline powder that is highly soluble … Mycophenolate

Mycophenolate Mofetil

Products Mycophenolate mofetil is commercially available in the form of film-coated tablets, capsules, as an injectable, and as a suspension (CellCept, generics). It has been approved in many countries since 1995. Structure and properties Mycophenolate mofetil (C23H31NO7, Mr = 433.5 g/mol) exists as a white crystalline powder and is practically insoluble in water. It is … Mycophenolate Mofetil