Helicobacter Pylori Infection: Complications

The following are the most important diseases or complications that may be contributed to by Helicobacter pylori infection:

Circulatory system (I00-I99)

Mouth, esophagus (food pipe), stomach, and intestines (K00-K67; K90-K93).

  • Chronic gastritis (chronic gastritis) (synonym: type B gastritis).
  • Dyspepsia (irritable stomach syndrome).
  • Ulcus duodeni (duodenal ulcer)
  • Ulcus ventriculi (gastric ulcer)

Neoplasms – tumor diseases (C00-D48)

  • Gastric carcinoma (stomach cancer) (due totype B gastritis).
    • 90% of all noncardiac and 20% of all cardiamalignomas are attributed to Helicobacter pylori infection induced
    • Gastric cancer risk is three times higher in H. pylori-infected individuals than in uninfected individuals
    • For noncardiac carcinoma, patients with H. pylori infection who did not have antibodies to CagA (chronic atrophic gastritis) showed a 5.2-fold increased risk of cancer.
    • Risk of distal gastric cancer is increased 2 to 3-fold by Helicobacter pylori infection.
  • MALT lymphoma (lymphomas of mucosa-associated lymphoid tissue, MALT); so-called extranodal (arising outside the lymph nodes) lymphomas; about 50 % of all MALT lymphomas are diagnosed in the stomach (80 % in the gastrointestinal tract) (90 % of MALT lymphomas of the stomach are Helicobacter pylori-positive); MALT lymphomas are largely caused by chronic infections with the bacterium Helicobacter pylori (type B gastritis) or by inflammations of the gastric tract. favored by inflammation; by eradication therapy (antibiotic therapy) disappear not only the bacteria, but as a result in 75% of cases also the gastric lymphoma.

Prognostic factors

  • Helicobacter pylori strains isolated from patients with iron deficiency were significantly more aggressive in studies and caused more severe inflammation than those from patients without iron deficiency.