Hemophilia: Classification

Classification of hemophilia according to factor activity.

Factor activity: factor VIII/factor IX Assessment Clinical symptoms
25-50 % Subhemophilia Mostly without symptoms
5-25 % Mild hemophilia Usually asymptomatic, possibly postoperative secondary hemorrhage or hematoma after more severe trauma (injury)
1-5 % moderate hemophilia Bleeding after minor trauma
< 1 % severe hemophilia Spontaneous bleeding