Hemophilia: Test and Diagnosis

Laboratory parameters of the 1st order – obligatory laboratory tests.

  • Small blood count
  • Coagulation parameters – PTT [↑], Quick [normal].
  • Determination of clotting factors:
    • VIII (hemophilia A),
    • IX (hemophilia B),
    • VWF (von Willebrand factor; synonyms: Clotting factor VIII-associated antigen or von Willebrand factor antigen, vWF-Ag).

Severity of hemophilia

Severity Factor level in %
Severe hemophilia < 1 %
Moderate hemophilia 1-5 %
Mild hemophilia 5-40 %

2nd order laboratory parameters – depending on the results of the history, physical examination and obligatory laboratory parameters – for differential diagnostic clarification

  • Inflammatory parameters – CRP (C-reactive protein) or ESR (erythrocyte sedimentation rate).
  • Liver parameters – alanine aminotransferase (ALT, GPT), aspartate aminotransferase (AST, GOT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (gamma-GT, GGT), alkaline phosphatase, bilirubin.
  • Renal parameters – urea, creatinine, cystatin C or creatinine clearance, if necessary.