Laboratory parameters of the 1st order – obligatory laboratory tests.
- Small blood count
- Coagulation parameters – PTT [↑], Quick [normal].
- Determination of clotting factors:
- VIII (hemophilia A),
- IX (hemophilia B),
- VWF (von Willebrand factor; synonyms: Clotting factor VIII-associated antigen or von Willebrand factor antigen, vWF-Ag).
Severity of hemophilia
| Severity | Factor level in % |
| Severe hemophilia | < 1 % |
| Moderate hemophilia | 1-5 % |
| Mild hemophilia | 5-40 % |
2nd order laboratory parameters – depending on the results of the history, physical examination and obligatory laboratory parameters – for differential diagnostic clarification
- Inflammatory parameters – CRP (C-reactive protein) or ESR (erythrocyte sedimentation rate).
- Liver parameters – alanine aminotransferase (ALT, GPT), aspartate aminotransferase (AST, GOT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (gamma-GT, GGT), alkaline phosphatase, bilirubin.
- Renal parameters – urea, creatinine, cystatin C or creatinine clearance, if necessary.