The following are the most important diseases or complications that may be contributed to by hepatitis E:
Blood-forming organs – Immune system (D50-D90).
- Aplastic anemia – form of anemia (anemia) characterized by pancytopenia (synonym: tricytopenia; reduction of all three rows of cells in the blood; stem cell disease) and concomitant hypoplasia (functional impairment) of the bone marrow.
- Hemolytic anemia – forms of anemia (anemia) characterized by increased degradation or decay (hemolysis) of erythrocytes (red blood cells) and which can no longer be compensated for by increased production in the red bone marrow.
- Cryoglobulinemia – chronic recurrent immune complex vasculitis (immune disease of the vessels) characterized by the detection of abnormal cold precipitating serum proteins (cold antibodies).
- Thrombocytopenia – is present when the number of platelets (thrombocytes) in the blood is less than 150,000/μl (150 x 109/l)
Endocrine, nutritional and metabolic diseases (E00-E90).
- Hashimoto’s thyroiditis – autoimmune disease leading to chronic inflammation of the thyroid gland.
Infectious and parasitic diseases (A00-B99).
- Chronic hepatitis E – described in liver transplant recipients, kidney transplant recipients, and HIV-infected individuals.
Circulatory system (I00-I99)
- Myocarditis (inflammation of the heart muscle).
Liver, gallbladder, and bile ducts-pancreas (pancreas) (K70-K77; K80-K87).
- Acute liver failure – especially in pregnant women, individuals with chronic liver disease, and immunosuppressed individuals.
- Acute pancreatitis (inflammation of the pancreas) – HEV infection with genotype 1 in Southeast Asia.
- Liver cirrhosis – connective tissue remodeling of the liver leading to functional impairment.
Musculoskeletal system and connective tissue (M00-M99).
- Arthritis (inflammation of the joints)
- Myositis – inflammatory disease of the skeletal muscles.
Nervous system (G00-G99)
- Facial paresis – paresis (paralysis) of muscles innervated by the facial nerve, consequently part of the facial musculature is paralyzed.
- Guillain-Barré syndrome (GBS; synonyms: Idiopathic polyradiculoneuritis, Landry-Guillain-Barré-Strohl syndrome); two courses: acute inflammatory demyelinating polyneuropathy or chronic inflammatory demyelinating polyneuropathy (disease of the peripheral nervous system); idiopathic polyneuritis (diseases of multiple nerves) of spinal nerve roots and peripheral nerves with ascending paralysis and pain; usually occurs after infections.
- Meningoencephalitis – combined inflammation of the brain (encephalitis) and meninges (meningitis).
- Mononeuritis multiplex – inflammation of individual nerves in different parts of the body.
- Neuralgic shoulder amyotrophy (synonyms: English Parsonage-Turner syndrome) – inflammation of the brachial plexus (brachial plexus) by immune complexes.
- Peripheral neuropathy – damage to the peripheral nerves and.
- Vestibular neuritis – inflammation of the nerves belonging to the organ of balance.
Genitourinary system (N00-N99)
- Membranous glomerulonephritis (MGN) – the most common cause of nephrotic syndrome in adults; accounts for 20-30% of all glomerulonephritides; may be primary or secondary (resulting from other conditions)
- Membranoproliferative glomerulonephritis (MPGN) – associated with nephrotic syndrome in 50%.
- Mesangial IgA glomerulonephritis (IgA nephropathy, immunoglobulin A nephritis (IgAN)) – associated with the deposition of immunoglobulin A (Ig A) in the mesangium (intermediate tissue) of the glomeruli (renal corpuscles).
