Hives, Nettle Rash, Urticaria: Or something else? Differential Diagnosis

Skin and subcutaneous (L00-L99).

  • Acute urticaria
  • Allergic urticaria
  • Aquagenic urticaria – hives after water contact.
  • Cholinergic urticaria – hives caused by sweating or heavy exertion.
  • Chronic urticaria
  • Idiopathic urticaria – hives whose cause is unclear.
  • Contact urticaria
  • Periodic/recurrent urticaria
  • Urticaria due to cold/heat
  • Urticaria bullosa – hives associated with blistering.
  • Urticaria circinata – polycyclic limited foci.
  • Urticaria cum pigmentatione – hives, after which subsides hyperpigmentation occurs.
  • Urticaria e calore (heat urticaria).
  • Urticaria factitia – hives due to mechanical irritation.
  • Urticaria gigantea
  • Urticaria haemorrhagica – associated with hemorrhages.
  • Urticaria mechanica (pressure urticaria)
  • Urticaria pigmentosa – benign generalized proliferation of tissue mast cells.
  • Urticaria porcellanea – whitish edematous wheals.
  • Urticaria profunda – associated with deep edema formation.
  • Urticaria rubra – bright red discoloration of the wheals.
  • Urticaria solaris – urticaria triggered by solar radiation.
  • Urticaria vasculitis – systemic form of hives associated with vascular inflammation.

Infectious and parasitic diseases (A00-B99).

  • Hepatitis B infection
  • Hepatitis C infection
  • Infections, unspecified:
    • Bacteria
    • Parasites
    • Viruses

Musculoskeletal system and connective tissue (M00-M99).

  • Systemic lupus erythematosus (SLE) – autoimmune disease with formation of autoantibodies mainly against antigens of the cell nuclei (so-called antinuclear antibodies, ANA), in some circumstances also against blood cells and other body tissues.

Neoplasms – tumor diseases (C00-D48).

  • Chronic lymphocytic leukemia (CLL)

Injuries, poisoning, and other sequelae of external causes (S00-T98).

  • Angioedema – transient swelling of the subcutaneous tissue of the lip/lid region.
  • Serum sickness – type III hypersensitivity reaction of the immune system (immune complex disease) to a foreign, non-human protein, which is applied, for example, in vaccine sera or serum therapy. In addition, various drugs, such as sulfonamides and penicillins and other antigens can cause serum sickness

Drugs

Other differential diagnoses

  • Pressure
  • Mechanical irritation
  • Food allergies (to foods/additives, e.g. milk, eggs, fish (food allergens)).
  • Food preservatives
  • Food coloring agents
  • Plasma Expander
  • X-ray contrast agent
  • Solar radiation
  • Strong cold / heat
  • Strong effort