Hydroxybutyrate dehydrogenase (HBDH) is an enzyme that can be present in elevated levels in blood serum in various diseases. HBDH is composed of the two enzymes LDH1 and LDH2. It is found in the heart muscle as well as in the kidneys and erythrocytes (red blood cells).
Lactate dehydrogenase is mainly used in heart attack diagnostics.
An increase in HBDH can be expected after 6 to 12 hours after infarct onset.The maximum is reached after 48 to 144 hours after infarct onset.Normalization occurs after approximately 10 to 20 days.
The procedure
Material needed
- Blood serum
Preparation of the patient
- Not known
Disruptive factors
- None known
Standard values
| Normal value in U/l(new reference range) | Normal value in U/l(old reference range) | |
| Women | 135-215 | 55-140 |
| Men | 135-225 | 55-140 |
| Infants | < 500 | |
| Children | < 200 |
Indications
- Suspected anemia (anemia of the blood)
- Suspicion of myocardial infarction (heart attack)
Interpretation
Interpretation of increased values
- Anemia (anemia)
- Physical stress
- Myocardial infarction (heart attack)
- Renal infarction
Interpretation of decreased values
- Not relevant to the disease
Further notes
- If myocardial infarction is suspected, the following laboratory parameters should be determined:
- Myoglobin
- Troponin T (TnT)
- CK-MB (creatine kinase myocardial type).
- CK (creatine kinase)
- Aspartate aminotransferase (AST, GOT)
- LDH (lactate dehydrogenase)
- HBDH (hydroxybutyrate dehydrogenase)