Products
Ibuprofen lysinate is commercially available in the form of film-coated tablets and granules (e.g., Algifor-L, Ibufen-L, generics), among others. It has been approved in many countries since 1979.
Structure and properties
Ibuprofen lysinate (C19H32N2O4, Mr = 352.5 g/mol) is the salt of the natural amino acid lysine with the analgesic ibuprofen. Ibuprofen is negatively charged and lysine is positively charged. Ibuprofen is a racemate and a propionic acid derivative.
Effects
Ibuprofen lysinate (ATC M01AE01) has analgesic, antipyretic, anti-inflammatory, and mild antiplatelet properties. The effects are due to inhibition of cyclooxygenase and inhibition of the synthesis of prostaglandins. The half-life is short and is about two hours. The effect is more rapid if ibuprofen is taken in the form of the lysine salt rather than as an acid, because ibuprofen lysinate dissolves better in water and is thus absorbed more quickly. Ibuprofen is virtually insoluble in water. Effects begin after about 30 minutes. The maximum plasma concentration (Cmax) of conventional ibuprofen is not reached for 1 to 2 hours.
Indications
For the treatment of pain, fever, and inflammatory conditions.
Dosage
According to the professional information. The medicine is usually taken three times a day. The usual single dose for adults is 200 mg to 600 mg of ibuprofen.
Contraindications
Numerous precautions must be considered before use. Full details of precautions and drug interactions can be found in the Drug Information Leaflet.
Adverse effects
The most common possible adverse effects include gastrointestinal side effects such as nausea, vomiting fullness, heartburn, pain, diarrhea, and constipation, as well as hypersensitivity reactions. Like all NSAIDs, ibuprofen can rarely cause serious side effects, such as gastrointestinal ulcers, blood count changes, cardiovascular disease, and kidney disease. It should therefore be taken with caution and for as short a time as possible.
