Immunodeficiency: Complications

The following are the major diseases or complications that may be contributed to by immunodeficiency or immunodeficiency:

Respiratory system (J00-J99)

Skin and subcutaneous (L00-L99)

Infectious and parasitic diseases (A00-B99).

Neoplasms (C00-D48)

Actinic keratosis – facultative precancerous lesion of the skin (risk of degeneration: < 30%).
Lymphoma – congenital immunodeficiency increases the risk of lymphoma.

Special purpose code numbers (U00-U99).

Genitourinary system (N00-N99)

In the following immunologic emergencies, immediate contact should be made with a clinic experienced in immunodeficiency diagnosis and treatment:

Symptoms or laboratory values	Primary immunodeficiencies (PID)
Erythroderma (redness (erythema) of the entire skin organ) in the first weeks of life	Suspected severe combined immunodeficiency (SCID): group of genetic diseases (autosomal or X-linked recessive genetic defects) characterized by a complete absence of immune defense (inhibition of T-lymphocyte development as well as, possibly. Absence of B lymphocytes and NK lymphocytes); if untreated, most affected individuals die in infancy; prevalence (frequency of disease) approximately 1:70,000
Severe lymphopenia in the 1st year of life	Suspicion of severe combined immunodeficiency (see above).
Severe hypogammaglobulinemia	Suspicion of severe combined immunodeficiency or agammaglobulinemia
Persistent fever, lymphoproliferation, and cytopenia (decrease in the number of cells in the blood); neurologic disturbances	Suspicion of primary hemophagocytosis syndrome.
Severe neutropenia (decrease in neutrophil granulocytes) in infancy (<500/ l)	Suspicion of severe congenital neutropenia.

Addresses of appropriate clinics can be found on the API homepage (www.kinderimmunologie.de) and the DGfI homepage (www.immunologie.de).