Products
Indometacin has been approved in many countries since 1999 in the form of eye drops (Indophtal, Indophtal UD).
Structure and properties
Indomethacin (C19H16ClNO4, Mr = 357.8 g/mol) is an indoleacetic acid derivative. It exists as a white to yellow crystalline powder that is practically insoluble in water.
Effects
Indomethacin (ATC S01BC01) has analgesic and anti-inflammatory properties. The effects are due to inhibition of cyclooxygenase and inhibition of prostaglandin biosynthesis. In cataract surgery, indomethacin additionally prevents pupil constriction (miosis), thus facilitating the procedure. It is administered for this purpose before surgery.
Indications
- Inflammatory conditions of traumatic origin (ocular surgery, contusions) or atraumatic genesis (glaucoma therapy by laser, conjunctivitis).
- Preoperative pretreatment to maintain mydriasis during cataract surgery or surgery of the anterior segment of the eye.
- Prophylaxis of cystoid macular edema after cataract surgery.
Dosage
According to the professional information. Dosage depends on the indication.
Contraindications
- Hypersensitivity, including to other NSAIDs and acetylsalicylic acid.
- Asthma attacks after taking acetylsalicylic acid or other NSAIDs in patient history
- Gastric or intestinal ulcers
- Severe liver or kidney failure
- Last trimester of pregnancy
Full precautions can be found in the drug label.
Interactions
When other eye drops are used concomitantly, an interval of 15 minutes should be observed. Systemic drug-drug interactions cannot be ruled out.
Adverse effects
Possible adverse effects include local reactions such as mild burning or biting after administration, eye redness, and eyelid edema.
