Indoxacarb

Products

Indoxacarb is commercially available as a drop-on solution for dogs and cats. It was approved in many countries in July 2012.

Structure and properties

Indoxacarb (C22H17ClF3N3O7, Mr = 527.8 g/mol) is a prodrug that is biotransformed to the active metabolite only in the insect by cleavage of the carbomethoxy group. It belongs to the chemical class of oxadiazines.

Effects

Indoxacarb (ATCvet QP53AX27) is insecticidal against larval, adult fleas, and other insects. The effects are due to blockade of sodium channels. The substance can be detected in the coat and skin for at least 4 weeks.

Indications

For the prevention and treatment of flea infestation. It can also be used as part of treatment of allergic flea dermatitis.

Dosage

According to the package insert. The solution is applied to the skin around the back of the animals every four weeks (spot-on).

Contraindications

Indoxacarb is contraindicated in cases of hypersensitivity. Refer to the drug label for complete precautions.

Interactions

Drug-drug interactions are not known. In our view, similar insecticidal flea medications should not be administered concomitantly.

Adverse effects

Possible adverse effects include transient increased salivation, pruritus, and hair loss. The drug may cause an oily appearance locally, sticking, crusting, and a short-term white residue.