Interaction | Arcoxia®


AnticoagulantsArcoxia® should not be given at the same time as anticoagulants or preparations of the same class of active ingredients (e.g. diclofenac / indometacin / piroxicam /Ibuprofen). In particular, when Marcumar® is administered at the same time, it should be taken into account that the blood-thinning effect of Marcumar® is increased. The effect of antihypertensive drugs (ACE inhibitors, beta blockers, diuretics) can be weakened.

Arcoxia shows interactions with the contraceptive pill. Since Arcoxia affects several enzymes of the liver metabolism, the contraceptive effect of the pill may be weakened. Even more important is another interaction: both Arcoxia and the pill increase the risk of thrombosis.

Taking both drugs at the same time is therefore potentially dangerous. This is especially true if there are other risk factors such as smoking, overweight or immobilization. The simultaneous intake of medication and alcohol is a problematic issue.

Alcohol enhances or weakens the effect of most medicines. Taking Arcoxia® over a longer period of time increases the risk of stomach ulcers. These ulcers can under certain circumstances cause life-threatening gastrointestinal bleeding.

These bleedings can be massively increased by the regular consumption of alcohol, as it has blood-thinning properties. In addition, regular alcohol consumption, especially in combination with other risk factors such as obesity or smoking, increases the risk of suffering a heart attack or thrombosis. Diseases of the cardiovascular system are also serious side effects while taking Arcoxia®.

The risk for such a disease increases significantly with alcohol consumption while taking Arcoxia®. Alcohol not only puts a strain on the heart and circulation, but also on the liver, as it metabolizes the alcohol. In some cases Arcoxia® also causes liver damage or restricts liver function. Again, when alcohol and Arcoxia® are taken at the same time, a double burden is placed on the body. It is therefore advisable to avoid alcohol as far as possible during therapy with Arcoxia® or similar drugs.


Since Arcoxia has several areas of application, there are many alternatives. In a specific case, it is therefore worth discussing the alternatives with the doctor treating the patient. The pain-relieving and anti-inflammatory effect is also shown by other NSAIDs to a very similar extent.

These include ASS, ibuprofen or diclofenac. A change can therefore be worthwhile, especially in the case of intolerances. For diseases such as rheumatoid arthritis or arthosis, there are also physical or even surgical therapies. Both can of course also be combined with Arcoxia.


You must not take Arcoxia® if you

  • Are or will become pregnant (use alternatives such as paracetamol)
  • Breastfeed
  • Have already had an allergic reaction to one of the ingredients of Arcoxia
  • Have already once had an allergic reaction to a drug from the drug group “sulfonamides” (used as antibiotics for cystitis, among other things). – allergic reactions such as skin rashes, swelling, itching or shortness of breath have occurred after taking Aspirin® or other non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen
  • Suffer from inflammatory bowel diseases (e.g. Crohn’s disease)
  • Have a stomach ulcer and/or duodenal ulcer
  • Have severe disorders of the liver and kidney
  • Have a very severe heart failure (decompensated heart failure)

During pregnancy, the use of medication must always be carefully considered. Many active substances can harm the unborn child.

Arcoxia® should not be taken during pregnancy because the drug inhibits the production of endogenous substances which, among other things, maintain the oxygen supply of the baby in the womb. It is also not recommended to take Arcoxia® during breastfeeding.