Interactions | Digitoxin

Interactions

Many factors and parallel administration of other medications can influence the digitoxin effect, therefore a precise anamnesis (systematic questioning of the patient about previous illnesses, medication intake, etc.) must be taken before prescription and administration. Factors that can cause interactions include Potassium concentration – hyperkalemia (increased potassium concentration) leads to reduced efficacy, hypokalemia (decreased potassium concentration), on the other hand, increases the effect and can therefore – when a normal dose is administered – lead to symptoms of poisoningKidney insufficiency – patients with kidney dysfunction should not be treated with digoxin, Digitoxin should be preferred here, as it is less excreted via the kidneysMedicines that activate or inhibit drug-degrading enzymes of the liver (induction or repression of CYP enzymes) These include some antibiotics, antiepileptics, St. John’s wort and antiarrhythmics.