Interactions

Cortisone cortisone: anticoagulant:

With simultaneous administration of cortisone, the risk of bleeding in the gastrointestinal tract increases considerably, and the occurrence of gastritis also increases significantly
Ibuprofen should not be given at the same time as anticoagulant preparations or preparations of the same class of active ingredients (diclofenac indometacin piroxicam). In particular with the simultaneous administration of Marcumar should be considered, which strengthens the blood-thinning effect of Marcumar.

Ibuprofen and alcohol should not be taken at the same time, because both substances are mainly metabolized in the liver. If ibuprofen and alcohol are taken together, they are broken down more slowly.

The consequence is that both accumulate in the body. Alcohol accumulates mainly in the brain, which leads to classic alcohol-related symptoms. These include lowering the inhibition threshold, loss of control, misjudgement of risks and perception disorders.

In addition, alcohol has hepatotoxic and neurotoxic effects, i.e. it directly destroys liver and brain cells. If ibuprofen accumulates in the body, it can lead to an overdose and massive side effects. Indications of this are: If such symptoms occur, it is essential to consult a doctor and stop taking any further ibuprofen.

Severe abdominal pain due to bleeding,
Nausea,
Vomiting,
Fluctuations in blood pressure,
Allergic reactions
And kidney and liver dysfunctions.

Contraindications

Contraindications for Ibuprofen are:

An existing stomach or intestinal ulcer
Several stomach or intestinal ulcers in the medical history
Bronchial asthma
Known liver diseases or kidney diseases
Pregnancy or breastfeeding(See Breastfeeding)

Ibuprofen in pregnancy

American researchers found out by means of a statistical study that the risk of miscarriage is increased by up to 80% if the pregnant woman takes aspirin or other painkillers at an early stage of pregnancy. In this study, 1000 pregnant women were examined and the results of the study were published in the scientific magazine “British Medical Journal” (vol. 327, p. 368).

The official name for the group of painkillers studied is Non-steroidal Aniphlogistics, which includes: These drugs are often prescribed for headache, menstrual pain and fever and are widely used in the population because they have few side effects relative to their effectiveness. Now, however, the use of these drugs in young women with the possibility of pregnancy must be strictly considered, as especially the intake around the time of conception can have a very critical effect on the development of pregnancy, according to the study. The reason for this increase in the probability of miscarriage may be that the painkiller group inhibits the formation of prostaglandins throughout the body.

However, these messenger substances, which also transmit pain stimuli in the central nervous system, also promote the implantation of the embryo in the uterus.If the formation of prostaglandins is now inhibited, it can lead to a more difficult implantation of the embryo in the uterus and thus later to a higher risk of miscarriage. In comparison to ibuprofen, pain medication such as paracetamol during pregnancy can be considered more beneficial because it only prevents the formation of prostaglandins in the central nervous system, but not in the rest of the body. Other studies have found that there is a slightly increased risk of cardiovascular disease and malformations of the child during ibuprofen intake and that in male children the testicles may be undescended at birth.

Ibuprofen,
Diclofenac,
Indomethacin and
Ketoprofen.

In the last third of pregnancy, non-steroidal anti-inflammatory drugs (NSAIDs) can lead to premature closure of the so-called ductus arteriosus Botalli in the unborn child. This premature closure is therefore harmful to the child, as the Ductus Botalli is essential for the intrauterine (=in the mother’s stomach) circulation. If it is erroneously closed in the mother’s abdomen due to medication such as ibuprofen, it can lead to heart failure in the unborn child, so that an emergency premature delivery must be initiated to save the child.

In addition, the connection between ibuprofen intake during pregnancy and high blood pressure, necrotizing intestinal inflammation (enterocolitis), and reduced kidney blood flow in the child has been observed. Finally, it can be summarized that any drug intake during pregnancy is to be considered extremely critical and that even in the case of painkillers, new findings are constantly leading to the conclusion that only in rare extremes should one be advised to take painkillers during pregnancy or the desire to have children if one does not want to increase the risk of miscarriage. & Ibuprofen during pregnancy