Products
Ferric maltol is commercially available in the form of hard capsules (Feraccru, some countries: Accrufer). It was approved in the EU in 2016 and in many countries in 2017.
Structure and properties
Ferric maltol contains ferric ions in a complex with three molecules of maltol (ferric trimaltol). Due to the complexation, iron is better absorbed compared with iron salts, according to the literature. Due to the better bioavailability, the dose can be reduced. At the same time, the potential for gastrointestinal irritation decreases because the iron is absorbed directly from the complex and no free iron enters the digestive tract. Maltol is a naturally occurring sugar derivative that is also used as a food additive (flavor enhancer).
Effects
The added iron (ATC B03AB10) substitutes the amount of iron lacking in the body. On the one hand, it is used to build hemoglobin, myoglobin, and enzymes, and on the other hand, it is stored in the liver, for example.
Indications
- For the treatment of iron deficiency in adults.
- In many countries: Treatment of iron deficiency anemia in adult patients with inflammatory bowel disease.
Dosage
According to the professional information. The capsules are usually taken in the morning and evening fasting.
Contraindications
- Hypersensitivity
- Hemochromatosis and other iron overload syndromes.
- Patients who receive repeated blood transfusions
Full precautions can be found in the drug label.
Interactions
Ferric maltol should not be combined with intravenous iron. Iron may reduce the absorption of other agents and should therefore be taken two to three hours apart (e.g., tetracyclines, levothyroxine, levodopa). This may also inhibit the absorption of iron. Combination with dimercaprol, chloramphenicol, and methyldopa should be avoided.
Adverse effects
The most common potential adverse effects include gastrointestinal disturbances such as abdominal pain, flatulence, constipation, abdominal discomfort, distended abdomen, and diarrhea.
