Irritable Stomach (Functional Dyspepsia): Drug Therapy

Therapy goals

  • Improvement of the symptomatology
  • Improvement of disease management
  • If necessary, freedom from symptoms

Therapy recommendations

Further notes

  • In FD complaints of the PDS (postprandial stress syndrome; postprandial distress syndrome; see classification below) phenotype, proton pump inhibitors and prokinetics should not be considered first-line therapies.
  • Notice: After successful Helicobacter pylori eradication, sustained therapy with a proton pump inhibitor (proton pump inhibitors, PPI; acid blockers) resulted in a 2.44-fold increased risk (95 percent confidence interval: 1.42-4.20) of gastric cancer.

Phytotherapeutics

  • STW 5 (effect on motility of the lower esophageal sphincter and colon); evidence level 1; dosage information: 3 × 20 drops.
  • Methacarin (active ingredient combination of peppermint and caraway oil); Evidence level 2; Dosage instructions: 2 × 1 capsule.
  • Peppermint / caraway oil

Supplements (dietary supplements; vital substances)

Suitable dietary supplements should contain the following vital substances: