Products
The ivermectin cream Soolantra was approved in many countries in 2016 (US: 2014).
Structure and properties
Ivermectin is a mixture of the two ivermectin components H2B1a and H2B1b. The two molecules differ structurally only by a methylene group. Ivermectin exists as a white to yellowish white, crystalline and weakly hygroscopic powder. The macrocyclic lactone is practically insoluble in water. It is a semisynthetic derivative of an avermectin formed by . This organism was discovered in a soil sample from Japan.
Effects
Ivermectin (ATC D11AX22) has antiparasitic, acaricidal, and anti-inflammatory properties. The exact mechanism of action is not known. Ivermectin is effective against -mites (, ), which may be involved in the pathogenesis of rosacea.
Indications
For the external treatment of inflammatory lesions in moderate to severe papulopustular rosacea.
Dosage
According to the SmPC. The cream is applied once daily for up to three months. Improvement is usually observed after one month.
Contraindications
The cream is contraindicated in case of hypersensitivity. Full precautions can be found in the drug label.
Adverse effects
The most common possible adverse effects include a burning sensation on the skin, skin irritation, itching, and skin dryness.
