Laboratory parameters of 1st order – obligatory laboratory tests.
- Small blood count [thrombocytopenia; decrease in platelets/platelets].
- Inflammatory parameters – CRP (C-reactive protein) or PCT (procalcitonin).
- Liver parameters – alanine aminotransferase (ALT, GPT), aspartate aminotransferase (AST, GOT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (gamma-GT, GGT), alkaline phosphatase, bilirubin.
- Renal parameters – urea, creatinine, cystatin C or creatinine clearance, if necessary.
- Coagulation parameters – PTT, Quick
- Blood cultures (direct pathogen detection is the method of choice).
- If necessary, AK detection (microagglutination test)of: Leptospira canicola; Leptospira grippotyphosa, Leptospira icterohemorrhagiae; Leptospira sejroe; leptospiral antibody Weil’s diseaseCave: cross-reactions between different serovars.
- If necessary, PCR (polymerase chain reaction) from blood/urine/liquor/tissue.
Laboratory parameters 2nd order – depending on the results of the history, physical examination and the obligatory laboratory parameters – for differential diagnostic clarification.
- CSF puncture (collection of cerebrospinal fluid by puncture of the spinal canal) for CSF diagnosis.
