Leukoplakia of Oral Mucosa: Surgical Therapy

1. dental surgery

  • Removal of non-salvageable, sharp-edged, mechanically irritating teeth/root debris.

2. oral and maxillofacial surgery.

  • Biopsy (tissue sample) – if a precursor lesion is suspected: any lesion without a tendency to regress after elimination of an adequate cause or observation for two weeks is considered suspicious.
  • Without/mild epithelial dysplasia (SIN I):
    • Initially, further observation possible.
    • Decision to excise (surgically remove tissue) dependent on location, extent, and general health status
  • Moderate/higher grade epithelial dysplasia (SIN II and III):
    • Complete excision of the leukoplakia in healthy tissue.
  • Alternatives to surgical excision – carry the risk of increased recurrence (recurrence of disease) and frequent side effects:
    • Laser therapy
      • CO2 laser
      • Erbium Yag laser
    • Cryosurgery – targeted icing of the tissue.
    • Photodynamic therapy (PDT) – procedure for the treatment of tumors with light in combination with a light-activatable substance, a so-called photosensitizer.