Licorice: Effect and Side Effects

The flavonoids contained in the root have an anti-inflammatory effect by inhibiting the production of inflammatory mediators. The healing of ulcers is accelerated because the intake of licorice leads to the normalization of the disturbed mucus composition.

Animal studies have also shown antispasmodic, expectorant and mucus expectoration facilitating effects. Anti-allergic and antimicrobial effects, especially against the causative agent of ulcers (Helicobacter pylori), have also been demonstrated.

Side effects of licorice

Prolonged use for more than 4 weeks and high doses (more than 50 g/day) may cause a shift in electrolyte concentrations in the body such as hypokalemia (too little potassium in the blood) or hypernatremia (too much sodium in the blood).

Water retention in the tissues (edema), high blood pressure, heart problems and, in extreme cases, myoglobinuria (excretion of myoglobin with the urine) are also conceivable with overdose. After discontinuation of the drug, the symptoms usually disappear quickly.

Interactions with licorice

Potassium loss may be exacerbated if other drugs that lead to potassium loss (for example, some dehydrating agents such as loop diuretics) are taken at the same time. To avoid cardiac arrhythmias, these drugs should not be taken with licorice root preparations.