Lipoprotein(a) Elevation (Hyperlipoproteinemia): Therapy

General measures

  • Adjustment of existing underlying diseases to optimal levels
  • Aim for normal weight! Determination of BMI (Body Mass Index, body mass index) or body composition by means of electrical impedance analysis and, if necessary, participation in a medically supervised weight loss program.
  • Nicotine restriction (refrain from tobacco use).
  • Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day).
  • Review of permanent medication due topossible effect on the existing disease.

Conventional non-surgical therapy methods

  • Lipid apheresis (extracorporeal LDL cholesterol apheresis; LDL apheresis; heparin-induced extracorporeal LDL precipitation (HELP); lipoprotein apheresis) for:
    • Homozygous familial hypercholesterolemia (hoFH).
    • In hypercholesterolemia, when the target LDL cholesterol (LDL-C) level cannot be adequately lowered with diet and maximal pharmacotherapy documented for 12 months
    • With isolated Lp(a) elevation > 60 mg/dl (ie, with normal LDL-C) but progressive cardiovascular disease (documented clinically and by imaging)

    Implementation of therapy is usually weekly; in about two to four hours, there is a 60-75% reduction in Lp(a).

Nutritional medicine

  • Nutritional counseling based on nutritional analysis
  • Observance of the following specific nutritional recommendations:
    • Reduce intake of saturated fatty acids and cholesterol.
    • Fresh sea fish once or twice a week, i.e. fatty marine fish (omega-3 fatty acids) such as salmon, herring, mackerel.
    • Plant stanol and plant sterol esters – mainly available in spreadable fats – lower LDL cholesterol levels by circa 10-15%.
    • Strongly limit consumption of foods with monosaccharides (single sugars) and disaccharides (double sugars).
    • Daily total of 5 servings of fresh vegetables and fruits (≥ 400 g; 3 servings of vegetables and 2 servings of fruits).
    • High-fiber diet (whole grains), preferably soluble fiber, contained in oat products, legumes, pectin-rich fruits such as apples, pears and berries.
  • Selection of appropriate foods based on the nutritional analysis
  • See also under “Therapy with micronutrients (vital substances)” – if necessary, taking a suitable dietary supplement.
  • Detailed information on nutritional medicine you will receive from us.

Sports Medicine

  • Endurance training (cardio training) and strength training (muscle training) → physical activity can sustainably reduce elevated fat levels in hyperlipoproteinemia
  • Preparation of a fitness or training plan with suitable sports disciplines based on a medical check (health check or athlete check).
  • Detailed information on sports medicine you will receive from us.