Products
Lufenuron is commercially available as a veterinary drug in tablet, suspension, and suspension for injection for cats. It has been approved in many countries since 1992.
Structure and properties
Lufenuron (C17H8Cl2F8N2O3, Mr = 511.2 g/mol) is a lipophilic, fluorinated and chlorinated benzoylphenylurea derivative. It is structurally closely related to diflubenzuron and exists as a white to yellowish powder that is sparingly soluble in water.
Effects
Lufenuron (ATCvet QP53BC01) has ovicidal and larvicidal properties. It inhibits the synthesis of chitin and thereby normal larval development. It is therefore also called insect-development inhibitor and insect-growth regulator. Unlike other flea medicines, lufenuron is administered orally or injected and does not act externally. This is an advantage in that no chemicals are deposited in the fur. When administered orally, the drug is absorbed into the blood and, due to its high lipophilicity, reaches the adipose tissue, from where it is released during approximately one month. The fleas absorb the active ingredient during the blood meal. Lufenuron does not kill adult fleas directly or only slowly and is therefore also combined with insecticides such as nitenpyram at the beginning of treatment.
Indications
Lufenuron is used to control and prevent flea infestations in dogs and cats.
Dosage
According to the package insert. Dosage is based on the body weight of the animal. The tablets and suspension are administered monthly with or immediately after a meal. Administration with food is important because it increases bioavailability. The injection suspension for cats only needs to be injected subcutaneously every 6 months.
Contraindications
For complete precautions, see the drug label.
Interactions
There are no known drug-drug interactions.
Adverse effects
Possible adverse effects include vomiting, depression, lethargy, loss of appetite, hyperactivity, respiratory disturbances, pruritus, and rash. Injection may cause local reactions such as pain, inflammation, and granulomas.
