Luliconazole

Products

Luliconazole is commercially available as a cream (Luzu). It was registered in the United States in 2013. The drug is not currently approved in many countries. In Japan, luliconazole has been on the market since 2005.

Structure and properties

Luliconazole (C14H9Cl2N3S2, Mr = 354.3 g/mol) is a chlorinated imidazole and 1,3-dithiolane derivative.

Effects

Luliconazole has antifungal properties against dermatophytes and . The effects are due to inhibition of the synthesis of ergosterol, which is essential for the fungal cell membrane.

Indications

For the treatment of fungal skin infections (tinea pedis, tinea cruris, tinea corporis).

Dosage

According to the professional information. The cream is applied thinly once daily. The duration of therapy is one or two weeks, depending on the indication.

Contraindications

Luliconazole is contraindicated in cases of hypersensitivity. For complete precautions, see the drug label.

Interactions

Luliconazole is a CYP inhibitor. However, when used topically, the likelihood of systemic drug interactions is low.

Adverse effects

Possible adverse effects include local skin reactions at the administration site.