Products
Luliconazole is commercially available as a cream (Luzu). It was registered in the United States in 2013. The drug is not currently approved in many countries. In Japan, luliconazole has been on the market since 2005.
Structure and properties
Luliconazole (C14H9Cl2N3S2, Mr = 354.3 g/mol) is a chlorinated imidazole and 1,3-dithiolane derivative.
Effects
Luliconazole has antifungal properties against dermatophytes and . The effects are due to inhibition of the synthesis of ergosterol, which is essential for the fungal cell membrane.
Indications
For the treatment of fungal skin infections (tinea pedis, tinea cruris, tinea corporis).
Dosage
According to the professional information. The cream is applied thinly once daily. The duration of therapy is one or two weeks, depending on the indication.
Contraindications
Luliconazole is contraindicated in cases of hypersensitivity. For complete precautions, see the drug label.
Interactions
Luliconazole is a CYP inhibitor. However, when used topically, the likelihood of systemic drug interactions is low.
Adverse effects
Possible adverse effects include local skin reactions at the administration site.