2nd order laboratory parameters – depending on the results of the history, physical examination, etc. – for differential diagnostic workup
- Culture of the virus in mice (isolation from blood or cerebrospinal fluid) – possible in the early phase.
Serological parameters in lymphocytic choriomeningitis infection
Illustration of LCMV-specific diagnostic markers, their possible combinations, and inferable infection status:
| LCMV-RNA (RT-PCR) | LCMV-IgG/IgM (ELISA/immunofluorescence). | Infection status | |
| IgM | IgG | ||
| positive | negative | negative | acute infection |
| positive | positive | negative | acute infection |
| positive | negative | positive | acute/ recent infection |
| positive | positive | positive | acute/ recent infection |
| negative | positive | positive | Recent infection or nonspecific LCMV IgM. |
| negative | negative | positive | expired infection |
