Musculoskeletal system and connective tissue (M00-M99).
- Fibrous dysplasia – malformation of bone tissue, that is, the bones form tumor-like projections.
- Bone infarction (demise of bone tissue).
- Paget’s disease (osteodystrophia deformans) – bone disease that leads to bone remodeling and gradually thickening of several bones, usually the spine, pelvis, extremities or skull.
- Osteomyelitis – acute or chronic inflammation of the bone and bone marrow, usually due to bacterial infection; combination of osteitis and myelitis (bone marrow/spinal cord)
Neoplasms – tumor diseases (C00-D48).
- Enchondroma – benign (benign) bone tumor arising from cartilage tissue.
- Fibrosarcoma (synonym: fibroplastic sarcoma) – malignant (malignant) tumor originating in connective tissue.
- Fibroxanthoma, atypical – solitary (occurring singly) rapidly growing (within a few months) fibrohistiocytic tumor of the skin; relatively benign (benign) clinical course.
- Liposarcoma – rare malignant (malignant) tumor of soft tissue with fine tissue characteristics of adipocytes (fat cells).
- Rhabdomyosarcoma – malignant soft tissue tumor that develops from cells of striated muscle.
- Metastases (formation of daughter tumors) – bronchial carcinoma (lung cancer), mammary carcinoma (breast cancer), malignant melanoma (“black skin cancer“).
Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99).
- Growing pains-about one-third of all children between 2 and 12 years of age occasionally suffer from growing pains; they usually occur in the evening or at night (80% of cases); the next morning, the child is able to move without pain and without restrictions
- Symptoms/complaints:
- Localizations:
- Front sides of the thighs
- Backs of knees
- Shins or calves
- Pain always occurs on both sides, alternating between both extremities if necessary, and can vary in intensity
- Joints are not affected
- Growing pains are pain at rest, not pain on exertion [diagnosis of exclusion! Conditions to clarify include rheumatic diseases, bone tumors, bone infections or unnoticed bone injury]
- Complaints are self-limiting
- Warning signs (red flags) of malignancy (malignant tumor): B symptoms (severe night sweats, unexplained persistent or recurrent (recurrent) fever (> 38 °C); unwanted weight loss (> 10% percent of body weight within 6 months)), back pain as the main localization, palpable mass, bleeding tendency, nonarticular bone pain (bone pain that does not involve a joint); abnormalities in the blood count and smear, LDH ↑
- Physical examination: no abnormal examination results.
- Laboratory diagnostics:
- Small blood count
- Differential blood count
- ESR (erythrocyte sedimentation rate)
- If necessary, also determination of transaminases, alkaline phosphatase (AP), LDH, creatinine.
- Medical Device Diagnostics:
- X-ray in two planes
- Magnetic resonance imaging (MRI) of the affected region.
Injuries, poisonings and other consequences of external causes (S00-T98).
- Injuries/sports injuries
