Pathogenesis (development of disease)
The cause of mastodynia, in the case of an endocrinologic disorder, is probably a shift in the estrogen-progesterone balance resulting in relative hyperestrogenism (relative predominance of estrogen action).
For the pathogenesis of the other diseases, see under the respective disease.
Etiology (causes)
Biographic causes
Disease-related causes.
Endocrine, nutritional, and metabolic diseases (E00-E90).
- Estrogen stimulus, unspecified.
- Hyperprolactinemia (see also under the disease hyperprolactinemia) – too high prolactin levels.
- Hyperandrogenemia – too high androgen level.
- Deficiency of thyroid hormones, unspecified
- Deficiency of progesterone, unspecified
Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99).
- Premenstrual syndrome (PMS) – occurs in women about four to fourteen days before their next period and involves a complex picture of different symptoms and complaints
Medication
- Hormones (estrogens)
- Mineralocorticoid receptor antagonist/aldosterone antagonists (spironolactone, eplerenone).