Memory Loss (Amnesia): Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90).

Cardiovascular system (I00-I99)

  • Apoplexy (stroke)
  • Intracranial hemorrhage (bleeding within the skull; parenchymal, subarachnoid, sub- and epidural, and supra- and infratentorial hemorrhage)/intracerebral hemorrhage (ICB; cerebral hemorrhage)

Infectious and parasitic diseases (A00-B99).

Mouth, esophagus (esophagus), stomach, and intestines (K00-K67; K90-K93).

Psyche – nervous system (F00-F99; G00-G99).

  • Alcohol abuse (alcohol dependence)
  • Delir
  • Depression
  • Epilepsy, severe
  • Dementia (e.g., due toAlzheimer’s disease, hypothyroidism (hypothyroidism), multi-infarct dementia).
  • Complex-partial seizures – form of epilepsy.
  • Limbic encephalitisbrain inflammation affecting the limbic system.
  • Personality disorder
  • Psychogenic memory disorders
  • Somatoform disorder/stress
  • Transient epileptic amnesia – special form of epilepsy.
  • Transient global amnesia (TGA) – acute onset memory lapses that last no more than 24 hours.

Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99)

  • Hypothermia (hypothermia)

Injuries, poisonings, and other sequelae of external causes (S00-T98).

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Medication / drugs

  • Antiepileptic drugs
    • KCNQ2/3 opener (retigabine).
  • Drug use (e.g., ecstasy intoxication).
  • Statins (simvastatin, atorvastatin; both agents are lipophilic and cross the bloodbrain barrier): In one study, physicians had reported various memory disturbances (ranging from isolated memory lapses to retrograde amnesia) in 3.03% of statin users during the course of therapy. These disturbances also occurred in 2.31% of statin nonusers. The adjusted odds ratio was 1.23, which was significant at a 95% confidence interval of 1.18 to 1.28. This indicates a slight increase in memory disorders. The association was more marked in the first 30 days of therapy (0.08% of statin users versus 0.02% of nonusers).
  • Drug side effects, unspecified