The following are the major diseases or complications that may be contributed to by metabolic (metabolic-related) acidosis:
Blood, hematopoietic organs – Immune system (D50-D90).
- Loss of activity of NK cells (natural killer cell; natural killer cells).
- Inhibition of lymphocyte proliferation (infection defense).
- Erythropoietin resistance (renal anemia).
Endocrine, nutritional, and metabolic diseases (E00-E90).
- Increase in parathyroid hormone (increase in ionized calcium).
- Diabetes mellitusType ” (due toInsulin resistance ↓)
- Increased protein catabolism
- Insulin resistance ↓
- Increase in endogenous corticoid secretion.
- Increase in extracellular potassium (hyperkalemia (excess potassium)).
- Increase in the inonized calcium
Infectious and parasitic diseases (A00-B99).
- At pH < 7.0, T cells (= T lymphocytes) can no longer kill tumor cells (increased risk of cancer) – this also increases the tendency to infections
- Reduction of ATP-mediated dissolution of tumor cells.
Musculoskeletal system and connective tissue (M00-M99).
- Arthralgia (joint pain)
- Muscle loss
- Myalgia (muscle pain)
- Osteopenia (reduction in bone density; precursor to osteoporosis); osteoporosis (bone loss).
Neoplasms – tumor diseases (C00-D48).
- At pH < 7.0, T cells (= T lymphocytes) can no longer kill tumor cells (increased risk of cancer) – this also increases the tendency to infections
Symptoms and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99).
- Hypercalcemia (calcium excess).
- Weakness in performance
Genitourinary system (kidneys, urinary tract – sex organs) (N00-N99)
- Progression of existing chronic renal insufficiency (kidney weakness).
Other consequences
- Decrease in enzyme activities
- Diffusion disorders and thus reduced supply of tissues with nutrients and vital substances (macro- and micronutrients).
- Osmotic change (swelling and deformation) of cells.
- Deterioration of oxygen utilization (oxygen use) and thus deterioration of organ functions (heart, kidneys, etc.)
- Decrease in vascular muscle response to catecholamines.
