Pathogenesis (disease development)
Meulengracht disease is an autosomal dominant inherited disorder that results in hyperbilirubinemia (increased presence of the bile pigment in the blood). There is decreased UDP-glucuronyltransferase and thus decreased formation of conjugated direct bilirubin. Thus, the serum level of indirect bilirubin increases.
Etiology (Causes)
Biographic causes
- Genetic burden from parents, grandparents (autosomal dominant).
Behavioral causes that may lead to increased bilirubin levels in Meulengracht disease:
- Alcohol consumption
- Fatigue
- Stress
- Decreased intake of calories
Disease-related causes that may lead to increased bilirubin levels in Meulengracht’s disease:
Other causes
- Passenger diseases, unspecified
