Products
Mitoxantrone is commercially available as an infusion/injection solution (Novantrone, generic). It has been approved in many countries since 1985.
Structure and properties
Mitoxantrone (C22H28N4O6, Mr = 444.5 g/mol)
Effects
Mitoxantrone (ATC L01DB07) has cytotoxic and immunosuppressive properties. The effects are due to inhibition of topoisomerase II and intercalation of DNA.
Indications
- Carcinomas, lymphomas, leukemia
- Multiple sclerosis with a rapidly progressive course.