Pathogenesis (disease development)
The etiology (cause) for psoriasis, and therefore also for nail psoriasis, is unclear to date. It is assumed that the coincidence of various factors is responsible for the development of the disease. These include, in addition to a genetic disposition, triggering factors such as infections, diseases or medications.
Streptococcal infections in particular can either trigger a psoriasis flare-up, or psoriasis can occur for the first time after a streptococcal infection. Some medications (see below) can also trigger psoriasis. Furthermore, psoriasis often develops on skin that has already been damaged.
Etiology (causes)
Biographic causes
- Genetic burden from parents, grandparents (polygenic disease; genetic contribution to psoriasis risk is approximately 60-70%).
Behavioral causes
- Consumption of stimulants
- Psycho-social situation
- Stress
- Pre-damaged skin – trauma, scratches, burns, chemical irritation, bumps, cracks, bites, sunburn.
Disease-related causes
- Infections – especially with streptococci.
Medication
- ACE inhibitors
- Beta-blockers
- Chloroquine
- Indomethacin may cause exacerbation in some patients with psoriasis
- Interferon
- Lithium
- NSAIDs (non-steroidal anti-inflammatory drugs)
