The following are the major diseases or complications that may be contributed to by nephrotic syndrome (not including the underlying disease(s)):
Respiratory system (J00-J99)
- Pleural effusion (excessive accumulation of fluid in the pleural cavity; due to albumin deficiency).
Endocrine, nutritional, and metabolic diseases (E00-E90).
- Hyperlipidemia/dyslipidemia (lipid metabolism disorders).
- Hypercholesterolemia (LDL cholesterol elevation).
- Hypertriglyceridemia (excessive triglyceride levels in the blood).
- Hypoproteinemia (reduced protein content in the blood), in this case hypalbuminemia (albumin deficiency) and associated decrease in the clotting factor antithrombin III (AT III) → thrombosis (thrombosis tendency is 50%).
- Short stature – term for a lower body length growth (below the 3rd percentile) not corresponding to the norm.
Skin and subcutaneous (L00-L99).
- Xanthelasma/yellowish raised plates in the tissues of the upper and lower eyelids containing cholesterol. (due to dyslipidemia/dyslipidemia).
Cardiovascular system (I00-I99).
- Hypertension (hypertension) – due to activation of the renin-angiotensin-aldosterone system.
- Pulmonary embolism
- Pericardial effusion (pericardial effusion; due toalbumin deficiency).
- Thrombosis (due torenal loss of antithrombin III (AT III)) (acute complication in the phase of nephrotic proteinuria).
Musculoskeletal system and connective tissue (M00-M99).
- Osteoporosis (bone loss)
Symptoms and abnormal clinical and laboratory findings not elsewhere classified (R00-R99).
- Ascites abdominal fluid; (due toalbumin deficiency).
- Edema (water retention)
- Proteinuria (increased excretion of protein in the urine).
Genitourinary system (N00-N99)
- Prerenal acute renal failure (acute complication in the phase of nephrotic proteinuria).
