Products
Nicethamide is contained in Gly-Coramine lozenges in many countries, which also contain glucose (dextrose). It was synthesized in Ciba laboratories in 1924. In 2010, Gly-Coarmine was sold by Novartis to Hänseler AG in many countries.
Structure and properties
Nicethamide or -diethylpyridine-3-carboxamide (C10H14N2O, Mr = 178.2 g/mol) is a derivative of nicotinamide, the amide of the vitamin niacin (vitamin B3). It exists as an oily liquid or crystalline mass. The colorless to slightly yellowish substance is miscible with water and ethanol 96%.
Effects
Nicethamide (ATC R07AB02) has central stimulant, respiratory stimulant, and circulatory stimulant properties.
Indications
For the treatment of fatigue associated with physical exertion and discomfort caused by exposure to high altitude or changes in atmospheric pressure, such as mountain walking.
Dosage
As directed. One lozenge is allowed to dissolve in the mouth as needed. Up to 10 lozenges may be administered throughout the day. The drug is approved for use by patients 16 years of age and older.
Abuse
Nicethamide is on the doping list and should not be administered during athletic competition. Athletes need to be aware that in some countries it is contained in dextrose tablets, which can lead to accidental ingestion and positive drug tests.
Contraindications
- Hypersensitivity
- Epilepsy
- Porphyria
- Hypertension
Nicethamide should not be administered during pregnancy and lactation. Full precautions can be found in the drug label.
Interactions
No information is available on potential drug-drug interactions.
Adverse effects
According to the SmPC, there are no known adverse effects. In the literature, the following side effects have been described in the event of improper use (overdose): Nausea, vomiting, flushing, itching, sneezing, sweating, anxiety, tremors, convulsions, restlessness, rapid pulse, hypertension, cardiac arrhythmias, agitation.
