Products
Nitenpyram is commercially available in tablet form (Capstar). It has been approved in many countries since 1999.
Structure and properties
Nitenpyram (C11H15ClN4O2, Mr = 270.7 g/mol) is a chlorinated pyridine derivative derived from nicotine. It is structurally related to imidacloprid.
Effects
Nitenpyram (ATCvet QP53BX02) has insecticidal properties. The effects are due to binding to nicotinic acetylcholine receptors and occur rapidly, within approximately 30 minutes. The drug is absorbed into the blood and enters the fleas during the blood meal. Nitenpyram has a half-life of 4-8 hours and is excreted within about 2 days. Thus, it does not have a long-lasting effect such as lufenuron, with which it can be combined.
Indications
For the immediate treatment of flea infestation in cats and dogs.
Dosage
According to the package insert. Nitenpyram is administered orally with or without food according to body weight.
Contraindications
Nitenpyram should not be used in animals that are too young. Refer to the drug label for complete precautions.
Interactions
There are no known interactions with other drugs.
Adverse effects
Possible adverse effects include itching in the first hour after administration.
