Therapeutic target
- Sleeping through the night without urinating.
Therapy recommendations
- You prioritize under “Further Therapy”
- If necessary, desmopressin (antidiuretic) for nocturnal polyuria (increased urination) in adults:
- Nasal therapy in the U.S.
- Oral 0.2 mg (max. 0.4 mg) before bedtime (Germany oral therapy only)
Active ingredients (main indication)
ADH (vasopressin)
| Active ingredient | Dosage | Special features |
| Desmopressin |
|
Wg. Risk of hyponatremia, sodium levels must be monitored before treatment and regularly during the course of therapy, |
- Mode of action: Stimulation V1 and V2 receptors → vasoconstriction (vasoconstriction), water reabsorption from renal tubules (antidiuretic).
- Indications:
- Nocturnal polyuria in adults
- Diabetes insipidus centralis
- Contraindications: Heart failure, poorly controlled diabetes mellitus, diseases of the bladder and prostate, polyuria as a side effect of various drugs (this must be excluded before prescribing).
- Dosage instructions: For long-term use, a treatment-free period of at least one week should be taken every 3 months to assess whether spontaneous improvement has occurred
- Side effects: Blood flow in the splanchnic area decreased, blood pressure increase, angina pectoris (“chest tightness”; sudden pain in the heart area), factor VIII and von Willebrandt factor ↑; hyponatremia.
- Wg. Risk of hyponatremia, sodium levels must be monitored before treatment and regularly during the course of therapy,
- To quickly notice water retention, the patient should weigh himself daily at the beginning of therapy.
