Products
Nystatin is commercially available as a monopreparation as an oral suspension (Mycostatin, Multilind). Combination preparations are also available. Nystatin has been approved in many countries since 1967.
Structure and properties
Nystatin (C47H75NO17, Mr = 926 g/mol) is a fungicidal substance obtained from certain strains of by fermentation. It consists largely of tetraenes, the major component of which is nystatin A1. It exists as a yellow to light brownish, hygroscopic powder that is practically insoluble in water.
Effects
Nystatin (ATC A07AA02) has antifungal properties against -yeasts. The effects are due to binding to sterols in the cell membrane of fungi and by altering cell membrane permeability.
Indications
Nystatin is used orally as a suspension to treat candidamycosis of the oral cavity, esophagus, and the rest of the digestive tract. A typical use is oral thrush. In the form of external dosage forms, it is further used for the treatment of Candida infections of the skin, for example, lice and intertrigo.
Dosage
According to the professional information.
Contraindications
- Hypersensitivity
For complete precautions, see the drug label.
Interactions
There are no known interactions with other medications.
Adverse effects
Possible adverse effects include hypersensitivity reactions and indigestion when taken orally. Skin reactions occur very rarely.
